Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis

Drug efflux pumps play important roles in intrinsic and acquired drug resistance. Verapamil, an efflux inhibitor that enhances the activity of bedaquiline, clofazimine, and other drugs against Mycobacterium tuberculosis, has been proposed as a potential adjunctive agent for treatment of tuberculosis...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Xu, Jian, Tasneen, Rokeya, Peloquin, Charles A., Almeida, Deepak V., Li, Si-Yang, Barnes-Boyle, Kala, Lu, Yu, Nuermberger, Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740328/
https://ncbi.nlm.nih.gov/pubmed/29038265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01692-17
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