Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis

Drug efflux pumps play important roles in intrinsic and acquired drug resistance. Verapamil, an efflux inhibitor that enhances the activity of bedaquiline, clofazimine, and other drugs against Mycobacterium tuberculosis, has been proposed as a potential adjunctive agent for treatment of tuberculosis...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Xu, Jian, Tasneen, Rokeya, Peloquin, Charles A., Almeida, Deepak V., Li, Si-Yang, Barnes-Boyle, Kala, Lu, Yu, Nuermberger, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740328/
https://ncbi.nlm.nih.gov/pubmed/29038265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01692-17
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