Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis

Drug efflux pumps play important roles in intrinsic and acquired drug resistance. Verapamil, an efflux inhibitor that enhances the activity of bedaquiline, clofazimine, and other drugs against Mycobacterium tuberculosis, has been proposed as a potential adjunctive agent for treatment of tuberculosis...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Xu, Jian, Tasneen, Rokeya, Peloquin, Charles A., Almeida, Deepak V., Li, Si-Yang, Barnes-Boyle, Kala, Lu, Yu, Nuermberger, Eric
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740328/
https://ncbi.nlm.nih.gov/pubmed/29038265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01692-17
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