A Sensitive In Vitro High-Throughput Screen to Identify Pan-Filoviral Replication Inhibitors Targeting the VP35-NP Interface

The 2014 Ebola outbreak in West Africa, the largest outbreak on record, highlighted the need for novel approaches to therapeutics targeting Ebola virus (EBOV). Within the EBOV replication complex, the interaction between polymerase co-factor, viral protein 35 (VP35), and nucleoprotein (NP) is critic...

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Publicat a:ACS Infect Dis
Autors principals: Liu, Gai, Nash, Peter J., Johnson, Britney, Pietzsch, Colette, Ilagan, Ma. Xenia G., Bukreyev, Alexander, Basler, Christopher F., Bowlin, Terry L., Moir, Donald T., Leung, Daisy W., Amarasinghe, Gaya K.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735849/
https://ncbi.nlm.nih.gov/pubmed/28152588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00209
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