A Sensitive In Vitro High-Throughput Screen to Identify Pan-Filoviral Replication Inhibitors Targeting the VP35-NP Interface

The 2014 Ebola outbreak in West Africa, the largest outbreak on record, highlighted the need for novel approaches to therapeutics targeting Ebola virus (EBOV). Within the EBOV replication complex, the interaction between polymerase co-factor, viral protein 35 (VP35), and nucleoprotein (NP) is critic...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Liu, Gai, Nash, Peter J., Johnson, Britney, Pietzsch, Colette, Ilagan, Ma. Xenia G., Bukreyev, Alexander, Basler, Christopher F., Bowlin, Terry L., Moir, Donald T., Leung, Daisy W., Amarasinghe, Gaya K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735849/
https://ncbi.nlm.nih.gov/pubmed/28152588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00209
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