Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Coagulation proteases have increasingly recognized functions beyond hemostasis and thrombosis. Disruption of activated protein C (aPC) or insulin signaling impair function of podocytes and ultimately cause dysfunction of the glomerular filtration barrier and diabetic kidney disease (DKD). We here sh...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Madhusudhan, Thati, Wang, Hongjie, Ghosh, Sanchita, Dong, Wei, Kumar, Varun, Al-Dabet, Moh'd Mohanad, Manoharan, Jayakumar, Nazir, Sumra, Elwakiel, Ahmed, Bock, Fabian, Kohli, Shrey, Marquardt, Andi, Sögüt, Ibrahim, Shahzad, Khurrum, Müller, Andreas J., Esmon, Charles T., Nawroth, Peter P., Reiser, Jochen, Chavakis, Triantafyllos, Ruf, Wolfram, Isermann, Berend
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2017
Sujets:
Thrombosis and Hemostasis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734620/
https://ncbi.nlm.nih.gov/pubmed/28687614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-767921
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