Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protei...

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Publicado no:Nat Commun
Main Authors: Madhusudhan, Thati, Wang, Hongjie, Dong, Wei, Ghosh, Sanchita, Bock, Fabian, Thangapandi, Veera Raghavan, Ranjan, Satish, Wolter, Juliane, Kohli, Shrey, Shahzad, Khurrum, Heidel, Florian, Krueger, Martin, Schwenger, Vedat, Moeller, Marcus J., Kalinski, Thomas, Reiser, Jochen, Chavakis, Triantafyllos, Isermann, Berend
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366504/
https://ncbi.nlm.nih.gov/pubmed/25754093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7496
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