Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protei...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Madhusudhan, Thati, Wang, Hongjie, Dong, Wei, Ghosh, Sanchita, Bock, Fabian, Thangapandi, Veera Raghavan, Ranjan, Satish, Wolter, Juliane, Kohli, Shrey, Shahzad, Khurrum, Heidel, Florian, Krueger, Martin, Schwenger, Vedat, Moeller, Marcus J., Kalinski, Thomas, Reiser, Jochen, Chavakis, Triantafyllos, Isermann, Berend
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366504/
https://ncbi.nlm.nih.gov/pubmed/25754093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7496
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