Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protei...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Madhusudhan, Thati, Wang, Hongjie, Dong, Wei, Ghosh, Sanchita, Bock, Fabian, Thangapandi, Veera Raghavan, Ranjan, Satish, Wolter, Juliane, Kohli, Shrey, Shahzad, Khurrum, Heidel, Florian, Krueger, Martin, Schwenger, Vedat, Moeller, Marcus J., Kalinski, Thomas, Reiser, Jochen, Chavakis, Triantafyllos, Isermann, Berend
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366504/
https://ncbi.nlm.nih.gov/pubmed/25754093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7496
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars