Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Shahzad, Khurrum, Bock, Fabian, Al-Dabet, Moh’d Mohanad, Gadi, Ihsan, Kohli, Shrey, Nazir, Sumra, Ghosh, Sanchita, Ranjan, Satish, Wang, Hongjie, Madhusudhan, Thati, Nawroth, Peter P., Isermann, Berend
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2016
Sujets:
Brief Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978051/
https://ncbi.nlm.nih.gov/pubmed/26832955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015060676
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