Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in theory, more likely to be relevant. Because pyro...

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Vydáno v:Blood
Hlavní autoři: Nazir, Sumra, Gadi, Ihsan, Al-Dabet, Moh’d Mohanad, Elwakiel, Ahmed, Kohli, Shrey, Ghosh, Sanchita, Manoharan, Jayakumar, Ranjan, Satish, Bock, Fabian, Braun-Dullaeus, Ruediger C., Esmon, Charles T., Huber, Tobias B., Camerer, Eric, Dockendorff, Chris, Griffin, John H., Isermann, Berend, Shahzad, Khurrum
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731086/
https://ncbi.nlm.nih.gov/pubmed/28882883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-782102
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