Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy

While a plethora of studies support a therapeutic benefit of Nrf2 activation and ROS inhibition in diabetic nephropathy (dNP), the Nrf2 activator bardoxolone failed in clinical studies in type 2 diabetic patients due to cardiovascular side effects. Hence, alternative approaches to target Nrf2 are re...

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Udgivet i:Sci Rep
Main Authors: Shahzad, Khurrum, Bock, Fabian, Al-Dabet, Moh’d Mohanad, Gadi, Ihsan, Nazir, Sumra, Wang, Hongjie, Kohli, Shrey, Ranjan, Satish, Mertens, Peter R., Nawroth, Peter P., Isermann, Berend
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056367/
https://ncbi.nlm.nih.gov/pubmed/27721446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34228
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