Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy

INTRODUCTION: IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose. Macroscopic hematuria during an upper respiratory tract infection is common amon...

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Veröffentlicht in:Kidney Int Rep
Hauptverfasser: Yamada, Koshi, Huang, Zhi-Qiang, Raska, Milan, Reily, Colin, Anderson, Joshua C., Suzuki, Hitoshi, Ueda, Hiroyuki, Moldoveanu, Zina, Kiryluk, Krzysztof, Suzuki, Yusuke, Wyatt, Robert J., Tomino, Yasuhiko, Gharavi, Ali G., Weinmann, Amy, Julian, Bruce A., Willey, Christopher D., Novak, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Translational Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733772/
https://ncbi.nlm.nih.gov/pubmed/29270528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ekir.2017.07.002
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