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Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

ZB716 is a selective estrogen receptor downregulator (SERD) with excellent oral bioavailability and superior efficacy. In this study, we investigate the in vitro and in vivo metabolism and the pharmacokinetics of ZB716 by incubation with liver microsomes, liver cytosol, and by orally dosing rodents....

詳細記述

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書誌詳細
出版年:Oncotarget
主要な著者: Zhang, Changde, Guo, Shanchun, Yang, Lin, Liu, Jiawang, Zheng, Shilong, Zhong, Qiu, Zhang, Qiang, Wang, Guangdi
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732773/
https://ncbi.nlm.nih.gov/pubmed/29262607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21808
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