Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

ZB716 is a selective estrogen receptor downregulator (SERD) with excellent oral bioavailability and superior efficacy. In this study, we investigate the in vitro and in vivo metabolism and the pharmacokinetics of ZB716 by incubation with liver microsomes, liver cytosol, and by orally dosing rodents....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Changde, Guo, Shanchun, Yang, Lin, Liu, Jiawang, Zheng, Shilong, Zhong, Qiu, Zhang, Qiang, Wang, Guangdi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732773/
https://ncbi.nlm.nih.gov/pubmed/29262607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21808
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