Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)

Orally bioavailable SERDs may offer greater systemic drug exposure, improved clinical efficacy, and more durable treatment outcome for patients with ER-positive endocrine-resistant breast cancer. We report the design and synthesis of a boronic acid modified fulvestrant (5, ZB716), which binds to ERα...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Liu, Jiawang, Zheng, Shilong, Akerstrom, Victoria L., Yuan, Chester, Ma, Youning, Zhong, Qiu, Zhang, Changde, Zhang, Qiang, Guo, Shanchun, Ma, Peng, Skripnikova, Elena V., Bratton, Melyssa R., Pannuti, Antonio, Miele, Lucio, Wiese, Thomas E., Wang, Guangdi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499704/
https://ncbi.nlm.nih.gov/pubmed/27529700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00753
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