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Deconstructing networks of p53-mediated tumor suppression in vivo

The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 activates a panoply of target genes and orchestrates numerous downstream responses that suppress tumorigenesis. Although earl...

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Bibliografski detalji
Izdano u:Cell Death Differ
Glavni autori: Kaiser, Alyssa M, Attardi, Laura D
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729531/
https://ncbi.nlm.nih.gov/pubmed/29099489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.171
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