Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL

New therapies for Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by a diverse array of kinase-activating alterations (including rearrangements, sequence mutations, and copy number alterations...

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Pubblicato in:Blood Adv
Autori principali: Roberts, Kathryn G., Yang, Yung-Li, Payne-Turner, Debbie, Lin, Wenwei, Files, Jacob K., Dickerson, Kirsten, Gu, Zhaohui, Taunton, Jack, Janke, Laura J., Chen, Taosheng, Loh, Mignon L., Hunger, Stephen P., Mullighan, Charles G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728345/
https://ncbi.nlm.nih.gov/pubmed/29296813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017011296
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