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Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S
Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants. Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.
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| Udgivet i: | Blood Adv |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727852/ https://ncbi.nlm.nih.gov/pubmed/29296783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007005 |
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