Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants. Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Fernández, José A., Xu, Xiao, Sinha, Ranjeet K., Mosnier, Laurent O., Sanner, Michel F., Griffin, John H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Stimulus Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727852/
https://ncbi.nlm.nih.gov/pubmed/29296783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007005
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