Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Activated protein C (APC) exerts endothelial cytoprotective actions that require protease-activated receptor 1 (PAR1), whereas thrombin acting via PAR1 causes endothelial disruptive, proinflammatory actions. APC's activities, but not thrombin's, require PAR1 located in caveolae. PAR1 is a...

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Detalhes bibliográficos
Main Authors: Mosnier, Laurent O., Sinha, Ranjeet K., Burnier, Laurent, Bouwens, Eveline A., Griffin, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537315/
https://ncbi.nlm.nih.gov/pubmed/23149848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-452169
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