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Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
The direct cytoprotective activities of activated protein C (APC) on cells convey therapeutic, relevant, beneficial effects in injury and disease models in vivo and require the endothelial protein C receptor (EPCR) and protease activated receptor 1 (PAR1). Thrombin also activates PAR1, but its effec...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731934/ https://ncbi.nlm.nih.gov/pubmed/23788139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-488957 |
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