Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the receptors and signaling mechanism through which aPC conveys cytoprotection in various cell types remain incompletely defined. Thus, within the renal glomeruli, aPC preserves endothelial cells via a proteas...

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Detalhes bibliográficos
Main Authors: Madhusudhan, Thati, Wang, Hongjie, Straub, Beate K., Gröne, Elisabeth, Zhou, Qianxing, Shahzad, Khurrum, Müller-Krebs, Sandra, Schwenger, Vedat, Gerlitz, Bruce, Grinnell, Brian W., Griffin, John H., Reiser, Jochen, Gröne, Hermann-Josef, Esmon, Charles T., Nawroth, Peter P., Isermann, Berend
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398751/
https://ncbi.nlm.nih.gov/pubmed/22117049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-365973
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