Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the receptors and signaling mechanism through which aPC conveys cytoprotection in various cell types remain incompletely defined. Thus, within the renal glomeruli, aPC preserves endothelial cells via a proteas...

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Bibliografische gegevens
Hoofdauteurs: Madhusudhan, Thati, Wang, Hongjie, Straub, Beate K., Gröne, Elisabeth, Zhou, Qianxing, Shahzad, Khurrum, Müller-Krebs, Sandra, Schwenger, Vedat, Gerlitz, Bruce, Grinnell, Brian W., Griffin, John H., Reiser, Jochen, Gröne, Hermann-Josef, Esmon, Charles T., Nawroth, Peter P., Isermann, Berend
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2012
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398751/
https://ncbi.nlm.nih.gov/pubmed/22117049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-365973
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