Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66(Shc)

The coagulation protease activated protein C (aPC) confers cytoprotective effects in various in vitro and in vivo disease models, including diabetic nephropathy. The nephroprotective effect may be related to antioxidant effects of aPC. However, the mechanism through which aPC may convey these antiox...

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Detalhes bibliográficos
Main Authors: Bock, Fabian, Shahzad, Khurrum, Wang, Hongjie, Stoyanov, Stoyan, Wolter, Juliane, Dong, Wei, Pelicci, Pier Giuseppe, Kashif, Muhammed, Ranjan, Satish, Schmidt, Simone, Ritzel, Robert, Schwenger, Vedat, Reymann, Klaus G., Esmon, Charles T., Madhusudhan, Thati, Nawroth, Peter P., Isermann, Berend
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545757/
https://ncbi.nlm.nih.gov/pubmed/23267072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218667110
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