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Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66(Shc)

The coagulation protease activated protein C (aPC) confers cytoprotective effects in various in vitro and in vivo disease models, including diabetic nephropathy. The nephroprotective effect may be related to antioxidant effects of aPC. However, the mechanism through which aPC may convey these antiox...

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Main Authors: Bock, Fabian, Shahzad, Khurrum, Wang, Hongjie, Stoyanov, Stoyan, Wolter, Juliane, Dong, Wei, Pelicci, Pier Giuseppe, Kashif, Muhammed, Ranjan, Satish, Schmidt, Simone, Ritzel, Robert, Schwenger, Vedat, Reymann, Klaus G., Esmon, Charles T., Madhusudhan, Thati, Nawroth, Peter P., Isermann, Berend
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545757/
https://ncbi.nlm.nih.gov/pubmed/23267072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218667110
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