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Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

The direct cytoprotective activities of activated protein C (APC) on cells convey therapeutic, relevant, beneficial effects in injury and disease models in vivo and require the endothelial protein C receptor (EPCR) and protease activated receptor 1 (PAR1). Thrombin also activates PAR1, but its effec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Burnier, Laurent, Mosnier, Laurent O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731934/
https://ncbi.nlm.nih.gov/pubmed/23788139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-488957
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