Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor.

In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated...

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Main Authors: Mosnier, Laurent O, Griffin, John H
Formato: Artigo
Idioma:Inglês
Publicado: 2003
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223481/
https://ncbi.nlm.nih.gov/pubmed/12683950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030341
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