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Factor V Is an Anticoagulant Cofactor for Activated Protein C during Inactivation of Factor Va

Coagulation factor V (FV) promotes inactivation of activated factor VIII (FVIIIa) by activated protein C (APC) and protein S. Loss of this APC cofactor activity is proposed to be partially responsible for the APC resistance phenotype of FV(Leiden). However, FVIIIa loses activity rapidly due to disso...

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Bibliografische gegevens
Hoofdauteurs: Cramer, Thomas J., Griffin, John H., Gale, Andrew J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: S. Karger AG 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974842/
https://ncbi.nlm.nih.gov/pubmed/20501981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000315141
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