SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer

EZH2 is crucial for the progression of prostate cancer (PCa) and castration-resistant prostate cancer (CRPC) through upregulation and activation of progenitor genes, as well as androgen receptor (AR)-target genes. However, the mechanisms by which EZH2 is regulated in PCa and CRPC remain elusive. Her...

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Pubblicato in:Oncogene
Autori principali: Lu, W, Liu, S, Li, B, Xie, Y, Izban, MG, Ballard, BR, Sathyanarayana, SA, Adunyah, SE, Matusik, RJ, Chen, Z
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724960/
https://ncbi.nlm.nih.gov/pubmed/27869166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.300
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