Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis. Loss of function of these factors due to phosphorylation and proteasomal degradation has been implicated in cell transformation and malignan...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Huang, Haojie, Regan, Kevin M., Wang, Fang, Wang, Diping, Smith, David I, van Deursen, Jan M. A., Tindall, Donald J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545492/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15668399/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406789102
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