Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis. Loss of function of these factors due to phosphorylation and proteasomal degradation has been implicated in cell transformation and malignan...

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Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Huang, Haojie, Regan, Kevin M., Wang, Fang, Wang, Diping, Smith, David I, van Deursen, Jan M. A., Tindall, Donald J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2005
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545492/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15668399/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406789102
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