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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis. Loss of function of these factors due to phosphorylation and proteasomal degradation has been implicated in cell transformation and malignan...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2005
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545492/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15668399/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406789102 |
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