SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on the regulation of JARID1B and H3K4me3 through epigenetic alterations still remain poorly understood. Here we report that Skp2...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lu, Wenfu, Liu, Shenji, Li, Bo, Xie, Yingqiu, Adhiambo, Christine, Yang, Qing, Ballard, Billy R., Nakayama, Keiichi I., Matusik, Robert J., Chen, Zhenbang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359254/
https://ncbi.nlm.nih.gov/pubmed/25596733
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