SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on the regulation of JARID1B and H3K4me3 through epigenetic alterations still remain poorly understood. Here we report that Skp2...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Lu, Wenfu, Liu, Shenji, Li, Bo, Xie, Yingqiu, Adhiambo, Christine, Yang, Qing, Ballard, Billy R., Nakayama, Keiichi I., Matusik, Robert J., Chen, Zhenbang
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359254/
https://ncbi.nlm.nih.gov/pubmed/25596733
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