Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist

Castration-resistant prostate cancer (CRPC) remains a major clinical challenge due to the lack of effective targeted therapy for its treatment. The mechanism underlying how CRPC gains resistance towards hormone depletion and other forms of chemotherapy is poorly understood. Research on understanding...

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Veröffentlicht in:Oncogene
Hauptverfasser: Ruan, Diane, He, Jiabei, Li, Chien-Feng, Lee, Hong-Jen, Liu, Jingxuan, Lin, Hui-Kuan, Chan, Chia-Hsin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532065/
https://ncbi.nlm.nih.gov/pubmed/28346424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.64
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