The DNA damage transducer RNF8 facilitates cancer chemoresistance and progression through Twist activation

Twist has been shown to cause treatment failure, cancer progression and cancer-related death. However, strategies that directly target Twist are not yet conceivable. Here we revealed K63-linked ubiquitination is a crucial regulatory mechanism for Twist activation. Through an E3 ligase screen and bio...

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Foilsithe in:Mol Cell
Main Authors: Lee, Hong-Jen, Li, Chien-Feng, Ruan, Diane, Powers, Scott, Thompson, Patricia A, Frohman, Michael A., Chan, Chia-Hsin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026628/
https://ncbi.nlm.nih.gov/pubmed/27618486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.009
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