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The DNA damage transducer RNF8 facilitates cancer chemoresistance and progression through Twist activation
Twist has been shown to cause treatment failure, cancer progression and cancer-related death. However, strategies that directly target Twist are not yet conceivable. Here we revealed K63-linked ubiquitination is a crucial regulatory mechanism for Twist activation. Through an E3 ligase screen and bio...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026628/ https://ncbi.nlm.nih.gov/pubmed/27618486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.009 |
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