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The E3 ubiquitin ligase RNF8 transduces the DNA damage signal via an ubiquitin-dependent signaling pathway
DNA damage signaling utilizes a multitude of post-translational modifiers as molecular switches to regulate cell cycle checkpoints, DNA repair, cellular senescence and apoptosis. Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA damage response. We...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2149842/ https://ncbi.nlm.nih.gov/pubmed/18001825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.09.041 |
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