Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

53BP1 is a well-known mediator of the cellular response to DNA damage. Two alternative mechanisms have been proposed to explain 53BP1’s interaction with DNA double-strand breaks (DSBs), one by binding to methylated histones and the other via an RNF8 E3 ligase–dependent ubiquitylation pathway. The fo...

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Hlavní autoři: Santos, Margarida Almeida, Huen, Michael S.Y., Jankovic, Mila, Chen, Hua-Tang, López-Contreras, Andrés J., Klein, Isaac A., Wong, Nancy, Barbancho, Juan L.R., Fernandez-Capetillo, Oscar, Nussenzweig, Michel C., Chen, Junjie, Nussenzweig, André
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2010
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867275/
https://ncbi.nlm.nih.gov/pubmed/20385748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092308
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