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The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection
TPP1, a component of the mammalian shelterin complex, plays essential roles in telomere maintenance. It forms a heterodimer with POT1 to repress ATR-dependent DNA damage signaling at telomeres, and recruits telomerase to chromosome ends. Here we show that the E3 ubiquitin ligase RNF8 localizes to an...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657743/ https://ncbi.nlm.nih.gov/pubmed/22101936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2172 |
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