The E3 ubiquitin ligase RNF8 transduces the DNA damage signal via an ubiquitin-dependent signaling pathway

DNA damage signaling utilizes a multitude of post-translational modifiers as molecular switches to regulate cell cycle checkpoints, DNA repair, cellular senescence and apoptosis. Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA damage response. We...

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Autori principali: Huen, Michael S.Y., Grant, Robert, Manke, Isaac, Minn, Kay, Yu, Xiaochun, Yaffe, Michael B, Chen, Junjie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149842/
https://ncbi.nlm.nih.gov/pubmed/18001825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.09.041
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