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Two-faced activity of RNF8: What “twists” it from a genome guardian to a cancer facilitator?
The RING finger protein 8 (RNF8)-induced ubiquitination signaling cascade promotes DNA repair and maintains genomic stability. Our study reveals an unexpected action of RNF8 in promoting cancer metastasis, cancer stem cell formation, and chemoresistance through the regulation of TWIST lysine 63 (K63...
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| Publicado no: | Mol Cell Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5160391/ https://ncbi.nlm.nih.gov/pubmed/28090581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1242454 |
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