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HectH9 hijacks glucose metabolism to fuel tumor growth
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH...
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| Udgivet i: | Mol Cell Oncol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736202/ https://ncbi.nlm.nih.gov/pubmed/31528705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1644599 |
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