HectH9 hijacks glucose metabolism to fuel tumor growth

Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Main Authors: Lee, Hong-Jen, He, Jiabei, Chan, Chia-Hsin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736202/
https://ncbi.nlm.nih.gov/pubmed/31528705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1644599
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