Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

The Myc-associated zinc-finger protein, Miz1, activates transcription of the p21cip1 gene in response to UV irradiation. Miz1 associates with topoisomerase II binding protein1 (TopBP1), an essential activator of the Atr kinase. We show here that Miz1 is required for the recruitment of a fraction of...

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Autori principali: Herold, Steffi, Hock, Andreas, Herkert, Barbara, Berns, Katrien, Mullenders, Jasper, Beijersbergen, Roderick, Bernards, Rene, Eilers, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580782/
https://ncbi.nlm.nih.gov/pubmed/18923429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.200
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