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Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1
The Myc-associated zinc-finger protein, Miz1, activates transcription of the p21cip1 gene in response to UV irradiation. Miz1 associates with topoisomerase II binding protein1 (TopBP1), an essential activator of the Atr kinase. We show here that Miz1 is required for the recruitment of a fraction of...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580782/ https://ncbi.nlm.nih.gov/pubmed/18923429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.200 |
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