Functional analysis of a CDKN2A 5’UTR germline variant associated with pancreatic cancer development

CDKN2A coding region germline variants are associated with pancreatic adenocarcinoma (PC) susceptibility. Recently, we described functional germline 5’UTR CDKN2A variants from melanoma patients affecting the post-transcriptional regulation of p16(INK4a) mRNA that is dependent, at least in part, on a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bruno, William, Andreotti, Virginia, Bisio, Alessandra, Pastorino, Lorenza, Fornarini, Giuseppe, Sciallero, Stefania, Bianchi-Scarrà, Giovanna, Inga, Alberto, Ghiorzo, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720692/
https://ncbi.nlm.nih.gov/pubmed/29216274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189123
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