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Functional analysis of a CDKN2A 5’UTR germline variant associated with pancreatic cancer development

CDKN2A coding region germline variants are associated with pancreatic adenocarcinoma (PC) susceptibility. Recently, we described functional germline 5’UTR CDKN2A variants from melanoma patients affecting the post-transcriptional regulation of p16(INK4a) mRNA that is dependent, at least in part, on a...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Bruno, William, Andreotti, Virginia, Bisio, Alessandra, Pastorino, Lorenza, Fornarini, Giuseppe, Sciallero, Stefania, Bianchi-Scarrà, Giovanna, Inga, Alberto, Ghiorzo, Paola
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720692/
https://ncbi.nlm.nih.gov/pubmed/29216274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189123
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