The 5′-untranslated region of p16(INK4a) melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

CDKN2A/p16(INK4a) is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16(INK4a) 5′UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16(INK4a) 5′...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Bisio, Alessandra, Latorre, Elisa, Andreotti, Virginia, Bressac-de Paillerets, Brigitte, Harland, Mark, Scarra, Giovanna Bianchi, Ghiorzo, Paola, Spitale, Robert C., Provenzani, Alessandro, Inga, Alberto
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2015
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741874/
https://ncbi.nlm.nih.gov/pubmed/26498684
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