The 5′-untranslated region of p16(INK4a) melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

CDKN2A/p16(INK4a) is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16(INK4a) 5′UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16(INK4a) 5′...

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Udgivet i:Oncotarget
Main Authors: Bisio, Alessandra, Latorre, Elisa, Andreotti, Virginia, Bressac-de Paillerets, Brigitte, Harland, Mark, Scarra, Giovanna Bianchi, Ghiorzo, Paola, Spitale, Robert C., Provenzani, Alessandro, Inga, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741874/
https://ncbi.nlm.nih.gov/pubmed/26498684
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