Soluble Aβ aggregates can inhibit prion propagation

Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrP(C)). Ligands that bind to PrP(C) can inhibit prion propagation and neurotoxicity. Extensive prior work established that cert...

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Bibliografiske detaljer
Udgivet i:Open Biol
Main Authors: Sarell, Claire J., Quarterman, Emma, Yip, Daniel C.-M., Terry, Cassandra, Nicoll, Andrew J., Wadsworth, Jonathan D. F., Farrow, Mark A., Walsh, Dominic M., Collinge, John
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717343/
https://ncbi.nlm.nih.gov/pubmed/29142106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170158
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