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Soluble Aβ aggregates can inhibit prion propagation
Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrP(C)). Ligands that bind to PrP(C) can inhibit prion propagation and neurotoxicity. Extensive prior work established that cert...
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| Pubblicato in: | Open Biol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Royal Society
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5717343/ https://ncbi.nlm.nih.gov/pubmed/29142106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170158 |
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