Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

Luminescent conjugated polymers (LCPs) interact with ordered protein aggregates and sensitively detect amyloids of many different proteins, suggesting that they may possess antiprion properties. Here, we show that a variety of anionic, cationic, and zwitterionic LCPs reduced the infectivity of prion...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Margalith, Ilan, Suter, Carlo, Ballmer, Boris, Schwarz, Petra, Tiberi, Cinzia, Sonati, Tiziana, Falsig, Jeppe, Nyström, Sofie, Hammarström, Per, Åslund, Andreas, Nilsson, K. Peter R., Yam, Alice, Whitters, Eric, Hornemann, Simone, Aguzzi, Adriano
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365923/
https://ncbi.nlm.nih.gov/pubmed/22493452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355958
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