Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

Luminescent conjugated polymers (LCPs) interact with ordered protein aggregates and sensitively detect amyloids of many different proteins, suggesting that they may possess antiprion properties. Here, we show that a variety of anionic, cationic, and zwitterionic LCPs reduced the infectivity of prion...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Margalith, Ilan, Suter, Carlo, Ballmer, Boris, Schwarz, Petra, Tiberi, Cinzia, Sonati, Tiziana, Falsig, Jeppe, Nyström, Sofie, Hammarström, Per, Åslund, Andreas, Nilsson, K. Peter R., Yam, Alice, Whitters, Eric, Hornemann, Simone, Aguzzi, Adriano
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365923/
https://ncbi.nlm.nih.gov/pubmed/22493452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355958
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